Hepatotoxicity and Lethality of Halogenoalkanes
نویسندگان
چکیده
treatment with carbenoxolone sodium resulted in thc increase of free and bound sialic acids to those values found in normal subjects, but no increase above control values was observed. The work now reported shows that treatment of normal adult rats with carbenoxolone results in significant increases in a number of components of the gastric mucus and mucosa. This may be related to the mechanism of the ulcer-healing action of the drug, and may provide a biological model for the evaluation of ulcer-healing potential. The present evidence indicates that the. major effect of carbenoxolone is on the carbohydrate moieties of glycoprotein and their incorporation into mucus.
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